Targeting inflammatory pathways
The research works towards a better understanding of the molecular pathways involved in immune response in human inflammatory pathologies and infectious diseases. Specifically, it studies the role of certain mediators of inflammation called cytokines, or the cellular processes in autoimmune, inflammatory disorders.
Evaluating the bromodomain protein BRD1 as a therapeutic target in rheumatoid arthritis
Interleukin-18 diagnostically distinguishes and pathogenically promotes human and murine macrophage activation syndrome
Unopposed IL-18 signaling leads to severe TLR9-induced macrophage activation syndrome in mice
Macroautophagy in dendritic cells (DCs) controls the stability of the regulatory T cell compartment and the severity of arthritis
The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts.
Viral infections as risk factors in chronic inflammatory disease
The prognostic value of viral detection and specific cytokine production in chronic inflammatory disease